Key result
Cardiac resynchronization therapy partially restores ventricular synchrony and improves systolic function, cardiac metabolism, and clinical parameters in patients with congestive heart failure.
This review summarizes the principles, effects, and non-responder identification for cardiac resynchronization therapy in heart failure patients with dyssynchrony.
In recent years cardiac resynchronization therapy has emerged as a promising new treatment strategy in a subgroup of patients with congestive heart failure and an asynchronous contraction pattern. By simultaneously pacing both right ventricular apex and lateral side of the left ventricle, ventricular synchrony can be partially restored and beneficial effects on cardiac performance can be observed. This review discusses the principles of ventricular dyssynchrony, and the acute and chronic effects of cardiac resynchronization therapy on systolic function, cardiac metabolism, and clinical parameters. Furthermore, the issue of identifying patients who do not respond to this therapy is addressed.
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Knaapen et al. (2005) conducted a review in Congestive heart failure with asynchronous contraction pattern. Cardiac resynchronization therapy was evaluated. Cardiac resynchronization therapy partially restores ventricular synchrony and improves systolic function, cardiac metabolism, and clinical parameters in patients with congestive heart failure.
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