Key result
Transcatheter tricuspid valve replacement is an emerging, feasible treatment option for patients with severe symptomatic tricuspid regurgitation who are at high or prohibitive surgical risk.
Why the study?
Severe tricuspid regurgitation carries a poor prognosis without treatment, and transcatheter options are needed for patients who are not candidates for surgery.
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Transcatheter tricuspid valve replacement is an emerging and feasible therapeutic option for patients with severe tricuspid regurgitation at high surgical risk, requiring careful patient selection and multimodality imaging.
Tricuspid regurgitation (TR) is a highly prevalent valve disorder in the US, with prevalence increasing with age. Without treatment, severe TR carries a poor prognosis. Tricuspid valve (TV) surgery is recommended for patients with severe TR undergoing left-sided valve surgery. Transcatheter TV repair or transcatheter TV replacement are potential options for patients who are not surgical candidates. A few small studies have demonstrated the feasibility and efficacy of transcatheter TV repair in patients with severe symptomatic TR. Careful patient selection by assessing tricuspid valve anatomy, right ventricular and pulmonary hemodynamics, candidacy for anticoagulation, comorbid conditions, and frailty is key to procedural success. Transcatheter TV repair can be performed via the transjugular or transfemoral access, and requires a large-caliber sheath (up to 45 Fr) and delivery system, particularly with dilated tricuspid annulus due to right ventricular enlargement. Multimodality imaging is essential for diagnosing TR severity, defining valve anatomy, and comprehensive functional assessment of the tricuspid valve, right atrium, and right ventricle. Several prosthetic valves, including the EVOQUE system, NaviGate system, Intrepid valve, and Cardiovalve, are currently being investigated in clinical trials.
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Shabbir et al. (2023) conducted a review in Severe tricuspid regurgitation. Transcatheter Tricuspid Valve Replacement (TTVR) was evaluated. Transcatheter tricuspid valve replacement is an emerging, feasible treatment option for patients with severe symptomatic tricuspid regurgitation who are at high or prohibitive surgical risk.
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