What question did this study set out to answer?

Review the adverse electrophysiological and clinical consequences of conventional right ventricular pacing and evaluate His bundle pacing as a physiological alternative.

March 9, 2019Journal of the American Heart AssociationOpen Access

His Bundle Pacing: A New Strategy for Physiological Ventricular Activation

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Why the study?

Right ventricular pacing causes ventricular dyssynchrony and adverse clinical outcomes, while current strategies to minimize it have not improved clinical outcomes.

Design

Review

Authors

ALAndrew LewisCardiac Imaging PFPaul FoleyGreat Western Hospital ZWZachary I. WhinnettElectrophysiology

Discussion

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Implication

May inform pacing decisions in select patients; leaves open randomized outcome data for His bundle pacing.

Key Points

Review the adverse electrophysiological and clinical consequences of conventional right ventricular pacing and evaluate His bundle pacing as a physiological alternative.
Narrative synthesis of clinical trial data examining outcomes associated with right ventricular pacing, including the DAVID and MOST trials.
Evaluation of pacing-induced ventricular dyssynchrony mechanisms and existing device-programming strategies designed to minimize right ventricular pacing.
Conventional right ventricular apical and septal pacing causes ventricular dyssynchrony, predisposing patients to impaired myocardial perfusion, valvular regurgitation, and higher heart failure hospitalization rates.
Efforts to minimize ventricular pacing using prolonged atrioventricular delays impair atrioventricular synchrony and fail to improve clinical outcomes, supporting His bundle pacing as a direct physiological activation target.

Cite This Study

Lewis et al. (2019) studied this question.

synapsesocial.com/papers/6a0e2b2bfeb2455d62c8338a https://doi.org/10.1161/jaha.118.010972

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Ask AI

Bookmark

His Bundle Pacing: A New Strategy for Physiological Ventricular Activation

Discussion

Member takes

Implication

Key Points

Cite This Study

His Bundle Pacing: A New Strategy for Physiological Ventricular Activation

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider