Key result
During upright exercise in normal men, stroke volume index increased from 41 to 58 ml/m2, driven by increased end-diastolic volume at low exertion and decreased end-systolic volume at high exertion.
Why the study?
How is stroke volume regulated during submaximal and maximal upright exercise in normal men?
Population
24 asymptomatic male volunteers
Comparison
Staged upright bicycle exercise to exhaustion vs Rest (baseline)
Design
Cross-sectional
Authors
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Supports biphasic SV regulation during upright exercise in normals; leaves open applicability to clinical populations.
Observational (n=24)
How is stroke volume regulated during submaximal and maximal upright exercise in normal men?
Stroke volume during upright exercise is regulated by the Starling mechanism at low exertion levels and by increased contractility (decreased end-systolic volume) at high exertion levels.
Higginbotham et al. (1986) conducted an observational in Healthy volunteers (n=24). Staged upright bicycle exercise to exhaustion vs. Rest was evaluated on Hemodynamic factors regulating stroke volume. During upright exercise in normal men, stroke volume index increased from 41 to 58 ml/m2, driven by increased end-diastolic volume at low exertion and decreased end-systolic volume at high exertion.
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