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March 31, 1959American Journal of Physiology-Legacy Content

Constancy of stroke volume in ventricular responses to exertion

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Why the study?

Does exercise or experimental tachycardia significantly alter stroke volume and ventricular dimensions in normal humans and intact dogs?

Population

Intact dogs and normal humans (including athletes and patients with chronic volume loads)

Comparison

Exercise/exertion and experimental tachycardia vs Rest

Design

Review

Authors

RRRobert F. RushmerUniversity of Washington

Discussion

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Overview

Stroke volume increase is unnecessary for normal exercise response; challenges historical concepts from indirect measures and leaves open direct validation needs.

Structured PICO

Does exercise or experimental tachycardia significantly alter stroke volume and ventricular dimensions in normal humans and intact dogs?

P
Population
Intact dogs and normal humans (including athletes and patients with chronic volume loads)
I
Intervention
Exercise/exertion and experimental tachycardia
C
Comparator
Rest
O
Outcome
Stroke volume and ventricular dimensionssurrogate

The paper highlights that increased stroke volume is not a mandatory feature of the normal cardiac response to exercise, challenging older concepts based on indirect measurements.

Cite This Study

Robert F. Rushmer (1959) studied this question.

synapsesocial.com/papers/6a701e98f44fa9f079dda952https://doi.org/10.1152/ajplegacy.1959.196.4.745
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Regulation of stroke volume during submaximal and maximal upright exercise in normal man.1986 · 533 citations
  2. 2Regulation of cardiac output by stroke volume and heart rate in conscious dogs.1978 · 54 citations
  3. 3Left Ventricular Ejection in Conscious Dogs:1966 · 30 citations
  4. 4Role of the Frank-Starling Mechanism In Exercise1972 · 73 citations
  5. 5Left Ventricular Response to Severe Exertion in Untethered Dogs1972 · 122 citations