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May 1, 1963Journal of Clinical InvestigationOpen Access

The Influence of Heart Rate on Left Ventricular Volume in Dogs*

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Why the study?

Do sudden changes in heart rate affect stroke, end-systolic, and end-diastolic volume in a canine model?

Population

Dogs (canine model)

Design

Preclinical

Authors

JBJames BristowThe Christie NHS Foundation TrustRFRichard FergusonBAE Systems (United States)FMFredric MintzSan Francisco General Hospital

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Overview

Does not support clinical heart rate changes; leaves open translation of canine LV volume effects to humans.

Structured PICO

Do sudden changes in heart rate affect stroke, end-systolic, and end-diastolic volume in a canine model?

P
Population
Dogs (canine model)
I
Intervention
Sudden changes in heart rate
O
Outcome
Stroke, end-systolic, and end-diastolic volume of the left ventricle measured by thermodilutionsurrogate

This preclinical study evaluates the physiological effects of sudden heart rate changes on left ventricular volumes in dogs.

Cite This Study

Bristow et al. (1963) studied this question.

synapsesocial.com/papers/6a76dd27e8156ceda1adfa0chttps://doi.org/10.1172/jci104755
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Constancy of stroke volume in ventricular responses to exertion1959 · 171 citations
  2. 2Effect of Ventricular Rate on the Cardiac Output in the Dog with Chronic Heart Block1962 · 95 citations
  3. 3Thermodilution studies of ventricular volume changes due to isoproterenol and bleeding1963 · 35 citations
  4. 4Left Ventricular Function in Mammals of Greatly Different Size1962 · 54 citations
  5. 5Effect of Plethora and Hemorrhage on Left Ventricular Volume and Pressure1957 · 39 citations