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October 1, 1963PEDIATRICS

Mechanisms of Adaptation of the Left Ventricle to Muscular Exercise

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Why the study?

Does treadmill exercise increase cardiac output and oxygen extraction in normal male subjects compared to rest?

Population

15 normal male subjects (and dog preparations)

Comparison

Treadmill exercise at the maximal oxygen intake… vs Rest in the standing position

Design

Other

Authors

JMJere H. Mitchell

Discussion

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Overview

During maximal exercise, the 9.5-fold increase in oxygen demand is met primarily by a 4.3-fold increase in cardiac output and a 2.2-fold increase in tissue oxygen extraction.

Structured PICO

Does treadmill exercise increase cardiac output and oxygen extraction in normal male subjects compared to rest?

P
Population
15 normal male subjects (and dog preparations)
I
Intervention
Treadmill exercise at the maximal oxygen intake level
C
Comparator
Rest in the standing position
O
Outcome
Changes in oxygen intake, cardiac output, estimated arteriovenous oxygen difference, pulse rate, and estimated mean stroke volumesurrogate

During maximal exercise, the 9.5-fold increase in oxygen demand is met primarily by a 4.3-fold increase in cardiac output and a 2.2-fold increase in tissue oxygen extraction.

Cite This Study

Jere H. Mitchell (1963) studied this question.

synapsesocial.com/papers/6a75e8d3fdf0921e0f786149https://doi.org/10.1542/peds.32.4.660
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