November 1, 1995Circulation
Target Heart Failure Populations for Newer Therapies
Population
500 ambulatory heart failure patients discharged on tailored medical therapy after evaluation for…
Design
Cohort
Follow-up
2 years
Authors
Discussion
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Member takes
Implication
May enable enrichment of high-event-rate severe HF cohorts; leaves open prospective validation for trial sizing.
Structured PICO
P
Population
500 ambulatory heart failure patients discharged on tailored medical therapy after evaluation for transplantation between 1988 and 1993.
O
Outcome
Death or need for urgent transplantation during the next 2 yearshard clinical
Ambulatory heart failure populations with high predicted event rates can be identified using ventricular dimension, serum sodium, and exercise capacity, which is crucial for appropriately sizing prospective trials of new therapies.
Cite This Study
Stevenson et al. (1995) studied this question.