In a rat model of postinfarction CHF, contractions triggered by L-type Ca2+ current were normal, suggesting the contractile deficit is only seen in undialyzed cardiomyocytes stimulated from -70 mV.
Authors
No takes yet. Share an insight, caveat, or question.
Normal L-type Ca²⁺-triggered contractions in this rat CHF model warrant no clinical change; leaves open voltage- and dialysis-dependent mechanisms in intact myocytes.
Sjaastad et al. (2002) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: