Key result
Myocyte loss via apoptosis exceeds necrotic cell death in the pathologic heart of ischemic origin, driving wall thinning and chamber dilation in heart failure.
Design
Review
Authors
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Apoptosis-targeted strategies merit exploration in ischemic HF; leaves open their clinical translation pending prospective trials.
Myocyte apoptosis is a key driver of wall thinning and chamber dilation in heart failure of ischemic origin.
Anversa et al. (1996) conducted a review in Heart failure. Myocyte loss via apoptosis exceeds necrotic cell death in the pathologic heart of ischemic origin, driving wall thinning and chamber dilation in heart failure.
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