Key result
A remote past LVEF ≥ 43.5% predicted response to CRT upgrade in patients with pacing-induced heart failure, yielding an AUC of 0.87 (sensitivity 78%, specificity 100%).
Why the study?
Does remote past left ventricular ejection fraction predict echocardiographic response to cardiac resynchronization therapy upgrade in patients with heart failure induced by chronic right ventricular pacing?
Population
25 consecutive patients who developed heart failure symptoms after long-term right ventricular pacing and…
Comparison
Cardiac resynchronization therapy (CRT) upgrade vs Non-responders to CRT upgrade
Design
Cohort
Follow-up
6 months
Authors
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May inform CRT upgrade selection in pacing-induced HF; hypothesis-generating, needs prospective validation.
Observational (n=25)
Does remote past left ventricular ejection fraction predict echocardiographic response to cardiac resynchronization therapy upgrade in patients with heart failure induced by chronic right ventricular pacing?
Effect estimate: AUC 0.87
Absolute Event Rate: 53.6% vs 31.4%
p-value: p=0.002
A remote past LVEF ≥ 43.5% prior to chronic right ventricular pacing strongly predicts a favorable echocardiographic response to CRT upgrade in patients who subsequently develop heart failure.
CHANG et al. (2013) conducted an observational in Heart failure after long-term right ventricular pacing (n=25). Cardiac resynchronization therapy (CRT) upgrade was evaluated on Response to CRT upgrade (reduction in LV end-systolic volume ≥ 15%) (AUC 0.87, p=0.002). A remote past LVEF ≥ 43.5% predicted response to CRT upgrade in patients with pacing-induced heart failure, yielding an AUC of 0.87 (sensitivity 78%, specificity 100%).
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