December 12, 1977JAMA
Long-Term Antiarrhythmic Therapy in Survivors of Prehospital Cardiac Arrest
Key result
A dose-adjusted, blood-level monitored antiarrhythmic drug regimen resulted in a 6% one-year mortality among survivors of prehospital cardiac arrest, comparing favorably to historical controls.
Why the study?
Does a dose-adjusted, blood-level monitored antiarrhythmic drug regimen reduce mortality and recurrent cardiac arrest in survivors of prehospital cardiac arrest?
Population
16 patients resuscitated from prehospital cardiac arrest
Comparison
Dose-adjusted, membrane-active antiarrhythmic… vs Historical cohort of survivors of prehospital…
Design
Cohort
Follow-up
average 13.25 months
Authors
Discussion
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Implication
May support monitored antiarrhythmic regimens in arrest survivors; leaves open randomized confirmation of benefit.
Study Design
Type
Cohort (n=16)
Structured PICO
Does a dose-adjusted, blood-level monitored antiarrhythmic drug regimen reduce mortality and recurrent cardiac arrest in survivors of prehospital cardiac arrest?
P
Population
16 patients resuscitated from prehospital cardiac arrest
I
Intervention
Dose-adjusted, membrane-active antiarrhythmic drug regimen monitored by blood levels
C
Comparator
Historical cohort of survivors of prehospital cardiac arrest not receiving a controlled antiarrhythmic program
O
Outcome
Mortality (one-year mortality)hard clinical
A blood-level monitored antiarrhythmic drug regimen may reduce mortality and recurrent cardiac arrest in prehospital cardiac arrest survivors, even if it fails to suppress asymptomatic complex ventricular arrhythmias.
Cite This Study
Robert J. Myerburg (1977) conducted a cohort in Survivors of prehospital cardiac arrest (n=16). Dose-adjusted, membrane-active antiarrhythmic drug regimen vs. Historical control (patients not receiving a controlled antiarrhythmic program) was evaluated on One-year mortality. A dose-adjusted, blood-level monitored antiarrhythmic drug regimen resulted in a 6% one-year mortality among survivors of prehospital cardiac arrest, comparing favorably to historical controls.