Key result
In an unselected hypertrophic cardiomyopathy population, isolated bursts of non-sustained ventricular tachycardia were not associated with adverse prognosis or significant differences in survival.
Why the study?
Does amiodarone treatment improve survival in unselected hypertrophic cardiomyopathy patients with multiple repetitive non-sustained ventricular tachycardia?
Cohort (n=167)
Does amiodarone treatment improve survival in unselected hypertrophic cardiomyopathy patients with multiple repetitive non-sustained ventricular tachycardia?
In an unselected HCM population, isolated NSVT does not justify chronic antiarrhythmic treatment, while low-dose amiodarone in patients with repetitive NSVT may prevent sudden cardiac death without adding mortality risk.
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Isolated NSVT may not warrant antiarrhythmic therapy in unselected HCM; leaves open amiodarone role in repetitive bursts.
Cecchi et al. (1998) conducted a cohort in Hypertrophic cardiomyopathy (n=167). Amiodarone vs. No amiodarone (patients without multiple repetitive NSVT) was evaluated on Cardiovascular mortality. In an unselected hypertrophic cardiomyopathy population, isolated bursts of non-sustained ventricular tachycardia were not associated with adverse prognosis or significant differences in survival.