Key result
The combination of aspirin with fluindione in elderly atrial fibrillation patients significantly increased nonfatal hemorrhagic complications (13.1% vs 1.2%, p=0.003) compared to fluindione alone.
Why the study?
Does the combination of fluindione and aspirin reduce stroke, myocardial infarction, systemic arterial emboli, or vascular death in patients with high-risk atrial fibrillation?
Population
157 patients with high-risk atrial fibrillation, average age 74 years, 52% women, 42% paroxysmal AF, in…
Comparison
Fluindione plus aspirin 100 mg, with an… vs Fluindione plus matching placebo, with an…
Design
RCT, randomized, double-blind, placebo-controlled
Follow-up
average 0.84 years
Authors
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Avoid adding aspirin to fluindione in elderly AF; challenges combination therapy and reinforces anticoagulation monotherapy.
RCT (n=157)
double-blind
randomized
Yes
Does the combination of fluindione and aspirin reduce stroke, myocardial infarction, systemic arterial emboli, or vascular death in patients with high-risk atrial fibrillation?
Adding aspirin to oral anticoagulation in elderly patients with high-risk atrial fibrillation significantly increases bleeding risk without a demonstrable thromboembolic benefit.
Lechat et al. (2001) conducted an RCT in high-risk atrial fibrillation (n=157). fluindione plus aspirin vs. fluindione plus placebo was evaluated on stroke (ischemic or hemorrhagic), myocardial infarction, systemic arterial emboli or vascular death. The combination of aspirin with fluindione in elderly atrial fibrillation patients significantly increased nonfatal hemorrhagic complications (13.1% vs 1.2%, p=0.003) compared to fluindione alone.
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