Key result
Myocardial T1 enhancement during bolus administration of intravascular and extracellular MR contrast agents in isolated canine tissue was strongly affected by myocardial water exchange.
The study demonstrates that myocardial T1 enhancement during bolus contrast administration is strongly affected by myocardial water exchange, challenging the assumption of fast water exchange.
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Caution in T1 modeling during bolus contrast; leaves open exchange-corrected quantification for human CMR.
Judd et al. (1995) studied this question. Intravascular and extracellular MR contrast agents was evaluated on Peak changes in myocardial 1/T1 (delta R1). Myocardial T1 enhancement during bolus administration of intravascular and extracellular MR contrast agents in isolated canine tissue was strongly affected by myocardial water exchange.
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