Key result
PVI plus dominant frequency ablation is linked to ~28% greater arrhythmia freedom in nonparoxysmal AF.
Why the study?
The relationship between high-dominant frequency sites and low-voltage areas in nonparoxysmal AF patients remained unknown, and the effect of ablation targeting these overlapping sites was unclear.
Does PVI followed by DF-based ablation improve atrial arrhythmia freedom compared to PVI alone in patients with nonparoxysmal atrial fibrillation?
Population
128 consecutive nonparoxysmal AF patients
Comparison
PVI followed by DF-based ablation vs circumferential PVI alone
Design
Retrospective study
Follow-up
10.0 ± 3.2 months
Authors
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May improve arrhythmia-free survival with DF ablation after PVI in nonparoxysmal AF; hypothesis-generating pending randomized confirmation.
Cohort (n=128)
Does PVI followed by DF-based ablation improve atrial arrhythmia freedom compared to PVI alone in patients with nonparoxysmal atrial fibrillation?
Absolute Event Rate: 83.1% vs 64.9%
p-value: p=0.021
Ablation targeting high-dominant frequency sites overlapping with low-voltage areas after PVI significantly improves atrial arrhythmia-free survival in patients with nonparoxysmal AF.
Kumagai et al. (2019) conducted a cohort in nonparoxysmal atrial fibrillation (n=128). Pulmonary vein isolation (PVI) followed by dominant frequency (DF)-based ablation vs. Circumferential PVI alone was evaluated on Atrial arrhythmia freedom on antiarrhythmic drugs (p=0.021). PVI followed by dominant frequency-based ablation significantly increased atrial arrhythmia freedom compared to PVI alone (83.1% vs 64.9%, P=0.021) in nonparoxysmal AF patients.
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