Key result
Aspirin prophylaxis significantly reduced venous thromboembolism compared to placebo after total hip replacement (25.0% vs 45.1%, P<0.03), though this protective effect was limited to men.
Why the study?
Does aspirin prevent venous thromboembolism in patients over 40 years of age after total hip replacement?
Population
95 patients over 40 years of age who had undergone total hip replacement
Comparison
Aspirin 600 mg twice daily vs Placebo
Design
RCT, double-blind
Authors
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Aspirin reduces VTE after hip replacement in men; supports targeted prophylaxis while extending evidence on sex-specific antithrombotic responses.
RCT (n=95)
Double-blind
Does aspirin prevent venous thromboembolism in patients over 40 years of age after total hip replacement?
Absolute Event Rate: 25% vs 45.1%
p-value: p=<0.03
Aspirin 600 mg twice daily significantly reduces the risk of venous thromboembolism in men over 40 after total hip replacement, but lacks a protective effect in women.
Harris et al. (1977) conducted an RCT in Venous thromboembolism after total hip replacement (n=95). Aspirin vs. Placebo was evaluated on Venous thromboembolism diagnosed by radiographic phlebography (p=<0.03). Aspirin prophylaxis significantly reduced venous thromboembolism compared to placebo after total hip replacement (25.0% vs 45.1%, P<0.03), though this protective effect was limited to men.
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