Key result
RV fibrosis in PH plays a dual role, preventing cardiomyocyte overstretch while maladaptively increasing stiffness.
Why the study?
The role of right ventricular fibrosis in pulmonary hypertension remains a subject of ongoing discussion, with uncertainty regarding its adaptive versus maladaptive impact on RV failure.
This review highlights the dual adaptive and maladaptive roles of right ventricular fibrosis in pulmonary hypertension, emphasizing the need for sensitive quantification techniques and novel therapeutic strategies.
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May guide cautious RV fibrosis assessment in PH; leaves open selective antifibrotic strategies and precise quantification.
Andersen et al. (2019) conducted a review in Pulmonary hypertension. Right ventricular fibrosis in pulmonary hypertension has a dual role, acting both as an adaptive response to prevent cardiomyocyte overstretch and a maladaptive response that increases stiffness.
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