January 1, 2001Cardiology
Long-Term Changes in Collagen Formation Expressed by Serum Carboxyterminal Propeptide of Type-I Procollagen and Relation to Left Ventricular Function after Acute Myocardial Infarction
Key result
An increase in s-PICP levels of >16.0 microg/l between days 1 and 90 after AMI was an independent predictor of cardiac death or heart failure during follow-up.
Why the study?
Do changes in serum PICP levels predict left ventricular remodeling and adverse clinical outcomes in patients following a first acute myocardial infarction?
Population
48 consecutive patients with their first acute myocardial infarction (AMI) and 15 control subjects.
Comparison
Change in serum carboxyterminal propeptide of… vs Change in s-PICP levels <=16.0 microg/l (Group I)
Design
Cohort
Follow-up
360 days for LV function, unspecified long-term for…
Authors
Discussion
Loading...
Member takes
Implication
May support post-AMI risk stratification with serial PICP; leaves open whether targeting fibrosis improves outcomes.
Study Design
Type
Cohort (n=63)
Structured PICO
Do changes in serum PICP levels predict left ventricular remodeling and adverse clinical outcomes in patients following a first acute myocardial infarction?
P
Population
48 consecutive patients with their first acute myocardial infarction (AMI) and 15 control subjects.
I
Intervention
Change in serum carboxyterminal propeptide of type-I procollagen (s-PICP) levels between days 1 and 90 >16.0 microg/l (Group II)
C
Comparator
Change in s-PICP levels <=16.0 microg/l (Group I)
O
Outcome
Left ventricular function (dilatation, ejection fraction, diastolic filling) from day 1 to 360, and composite of cardiac death or heart failure during follow-upsurrogate
An increase in serum PICP levels >16.0 microg/l over the first 90 days post-AMI is associated with adverse left ventricular remodeling and independently predicts cardiac death or heart failure.
Cite This Study
Poulsen et al. (2001) conducted a cohort in Acute myocardial infarction (n=63). Serum carboxyterminal propeptide of type-I procollagen (s-PICP) monitoring vs. DeltaPICP <=16.0 microg/l was evaluated on Cardiac death or heart failure and left ventricular function changes. An increase in s-PICP levels of >16.0 microg/l between days 1 and 90 after AMI was an independent predictor of cardiac death or heart failure during follow-up.