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January 1, 2025JACC Case ReportsOpen Access

Transcatheter Tricuspid Valve Replacement With EVOQUE and Mitral Valve Repair With PASCAL in One Procedure

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Key result

Simultaneous PASCAL mitral repair and EVOQUE tricuspid replacement successfully reduce regurgitation at one month.

  • n=1

Why the study?

It is still undetermined whether mitral and tricuspid regurgitation should be treated simultaneously or in stages.

Can simultaneous transcatheter mitral edge-to-edge repair and tricuspid valve replacement effectively treat severe mitral and torrential tricuspid regurgitation in a single procedure?

Population

1 patient with severe mitral and torrential tricuspid regurgitation

Comparison

Simultaneous mitral edge-to-edge repair with PASCAL Ace and TTVR with EVOQUE 48 mm

Design

Case report

Follow-up

1 month

Authors

VDVarius DannenbergCDCaglayan DemirelABAnna Bartunek

Discussion

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Overview

May support combined transcatheter mitral-tricuspid repair in select cases; leaves open durability, safety, and selection criteria.

Study Design

Type

Case Report (n=1)

Structured PICO

Can simultaneous transcatheter mitral edge-to-edge repair and tricuspid valve replacement effectively treat severe mitral and torrential tricuspid regurgitation in a single procedure?

P
Population
1 patient with severe dyspnea and leg edema diagnosed with severe mitral and torrential tricuspid regurgitation
I
Intervention
Simultaneous mitral edge-to-edge repair with PASCAL Ace and transcatheter tricuspid valve replacement with EVOQUE 48 mm in a single procedure
O
Outcome
Reduction in mitral and tricuspid regurgitation severity at 1 month follow-upsurrogate

Simultaneous transcatheter mitral edge-to-edge repair and tricuspid valve replacement is feasible and effective in a single procedure for patients with challenging anatomies.

Limitations

  • It is still being determined whether mitral and tricuspid regurgitation should be treated simultaneously or in stages
  • Tricuspid regurgitation may improve after mitral valve repair alone

Cite This Study

Dannenberg et al. (2025) conducted a case report in Severe mitral and torrential tricuspid regurgitation (n=1). Mitral edge-to-edge repair with PASCAL Ace and transcatheter tricuspid valve replacement with EVOQUE was evaluated on Reduction in tricuspid and mitral regurgitation. Simultaneous mitral edge-to-edge repair with PASCAL Ace and transcatheter tricuspid valve replacement with EVOQUE successfully reduced tricuspid regurgitation to trace and mitral to mild at 1 month.

synapsesocial.com/papers/6a0ecd9daa1655e5fb22d1c8https://doi.org/10.1016/j.jaccas.2024.102760
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Transfemoral tricuspid valve replacement and one-year outcomes: the TRISCEND study2023 · 253 citations
  2. 2Evolution of tricuspid regurgitation after transcatheter edge‐to‐edge mitral valve repair for secondary mitral regurgitation and its impact on mortality2022 · 72 citations
  3. 3Transcatheter Mitral-Valve Repair in Patients with Heart Failure2018 · 2,990 citations
  4. 4Secondary valve regurgitation in patients with heart failure with preserved ejection fraction, heart failure with mid-range ejection fraction, and heart failure with reduced ejection fraction2020 · 79 citations
  5. 5Large-scale community echocardiographic screening reveals a major burden of undiagnosed valvular heart disease in older people: the OxVALVE Population Cohort Study2016 · 723 citations