Key result
Heart failure with reduced ejection fraction was associated with a significantly higher risk of one-year all-cause mortality compared to heart failure with preserved ejection fraction (RR 3.276).
Why the study?
The new classification of heart failure according to ejection fraction needed exploration in black Africans to determine patient characteristics and prognosis across subtypes.
Cohort (n=251)
No
Effect estimate: RR 3.276 (95% CI 1.352-7.934)
p-value: p=0.009
In a Sub-Saharan African cohort, HFrEF was the most common heart failure subtype, but HFpEF was associated with better one-year survival despite older age and more comorbidities.
HFrEF linked to higher one-year mortality than HFpEF in this African cohort; leaves open subtype-specific strategies pending prospective validation.
Background: New classification of heart failure according to ejection fraction calls for exploring in black Africans. Objectives: To determine our patient's characteristics and prognosis of the subtypes of heart failure. Methods: We analysed data from consecutive black African patients hospitalised for heart failure at Heart Institute of Abidjan in 2018 and followed up for one year. Results: Were considered 251 heart failure patients (age: 55.5 ± 16.3 years, 63.7% of males) with preserved (HFpEF) (18.7%), mid-range (HFmrEF) (17.6%), and reduced ejection fraction (HFrEF) (63.7%). HFpEF patients were older (p <0.0001) and had more frequently. acute pulmonary oedema. From an echocardiographic point of view, HFpEF patients had, on average, a smaller left ventricle than the other patients (p <0.001), but a larger left atrium (p <0.05). Clinically, these patients were admitted more often with acute pulmonary oedema (p = 0.01) and had more often comorbidities (p=0.00)4. However, survival was better with HFpEF patients than HFrEF patients (log-rank = 4.61; p = 0.032). HFmrEF patients have an intermediate profile. Conclusion: In our context, although they have the same expression, HFrEF and HFPEF appear very different. We need further studies for a better understanding of HFmrEF.
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Adoubi et al. (2022) conducted a cohort in Heart failure (n=251). Heart failure with reduced ejection fraction (HFrEF) vs. Heart failure with preserved ejection fraction (HFpEF) was evaluated on All-cause mortality at 1 year (RR 3.276, 95% CI 1.352-7.934, p=0.009). Heart failure with reduced ejection fraction was associated with a significantly higher risk of one-year all-cause mortality compared to heart failure with preserved ejection fraction (RR 3.276).
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