Key result
Binding of the NS4A peptide to the HCV NS3 protease ordered the N-terminal 28 residues, causing local active site rearrangements and yielding a 2.2 Å resolution hexagonal crystal structure.
Authors
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May inform HCV protease inhibitor design; leaves open clinical translation of structural findings.
Yan et al. (1998) studied Hepatitis C. Binding of the NS4A peptide to the HCV NS3 protease ordered the N-terminal 28 residues, causing local active site rearrangements and yielding a 2.2 Å resolution hexagonal crystal structure.
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