Why the study?
The study investigated the relationship between subjective NYHA functional class and objective exercise capacity (VO2peak) in heart failure patients, and whether this relationship is influenced by medication adherence.
Does medication adherence influence the relationship between subjective NYHA class and objective exercise capacity in patients with heart failure?
Does medication adherence influence the relationship between subjective NYHA class and objective exercise capacity in patients with heart failure?
Objective functional capacity frequently exceeds subjective NYHA class in heart failure patients, and this discrepancy is not significantly influenced by medication adherence.
NYHA class may not reliably reflect exercise capacity in HF independent of adherence; leaves open other contributors to discordance.
Ăvod: Studie se zabĂ˝vala vztahem mezi subjektivnĂ klasifikacĂ New York Heart Association (NYHA) a objektivnĂ zĂĄtÄĹžovou kapacitou (mÄĹenou pomocĂ vrcholovĂŠho pĹĂjmu kyslĂku [VO2peak]) u pacientĹŻ se srdeÄnĂm selhĂĄnĂm a dĂĄle tĂm, zda je tento vztah ovlivnÄn adherencĂ k medikaci. Metody: Byly analyzovĂĄny Ăşdaje 170 pacientĹŻ se srdeÄnĂm selhĂĄnĂm z registru Level-CHF. Adherence byla hodnocena pomocĂ testovĂĄnĂ koncentrace lĂŠkĹŻ v sĂŠru. ObjektivnĂ zĂĄtÄĹžovĂĄ kapacita byla hodnocena pomocĂ spiroergometrie na bicyklovĂŠm ergometru. VĂ˝sledky: Hodnota objektivnĂ maximĂĄlnĂ spotĹeby kyslĂku Äasto pĹevyĹĄovala odpovĂdajĂcĂ subjektivnĂ tĹĂdu NYHA se 46% shodou, rozdĂly se projevovaly zejmĂŠna na krajnĂch koncĂch spektra. Byly zaznamenĂĄny drobnĂŠ odchylky v subjektivnĂm hodnocenĂ tĹĂdy NYHA v souvislosti s adherencĂ k medikaci, ale nebyly pozorovĂĄny ŞådnĂŠ podstatnĂŠ rozdĂly. ZĂĄvÄr: VĂ˝sledek upozorĹuje na rozdĂly mezi subjektivnĂm a objektivnĂm hodnocenĂm funkÄnĂ kapacity u pacientĹŻ se srdeÄnĂm selhĂĄnĂm. To by mÄlo vĂŠst k vÄtĹĄĂmu vyuĹžĂvĂĄnĂ objektivnĂch mÄĹenĂ pĹi klinickĂŠm rozhodovĂĄnĂ na zĂĄkladÄ funkÄnĂ kapacity a k vyuĹžĂvĂĄnĂ pĹĂmo mÄĹenĂ˝ch hodnot VO2peak nad subjektivnĂ tĹĂdou NYHA. DodrĹžovĂĄnĂ medikace vĂ˝znamnÄ nezmÄnilo subjektivnÄ-objektivnĂ trendy NYHA. © 2023, ÄKS.
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Jelínek et al. (2023) studied this question.
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