Why the study?
Does ischaemic preconditioning reduce ischaemia-reperfusion injury in aged, diabetic rat hearts?
Population
Aged, diabetic Goto-Kakizaki rats
Comparison
Ischaemic preconditioning (IPC) vs Younger diabetic rat hearts
Design
Preclinical
Key result
Ischaemic preconditioning failed to provide cardioprotection in isolated hearts of aged, diabetic Goto-Kakizaki rats compared with younger diabetic rats, likely due to impaired Akt signalling.
Authors
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Ischaemic preconditioning may fail in aged diabetic rat hearts; leaves open whether Akt modulation can restore protection in this model.
Does ischaemic preconditioning reduce ischaemia-reperfusion injury in aged, diabetic rat hearts?
Aged, diabetic rat hearts show increased susceptibility to ischaemia-reperfusion injury and resistance to ischaemic preconditioning, likely due to impaired Akt signalling from chronic Akt phosphorylation.
Whittington et al. (2013) studied Ischaemia-reperfusion injury in aging, diabetic heart. Ischaemic preconditioning (IPC) vs. Younger diabetic rat hearts was evaluated on Susceptibility to sub-lethal injury and achievability of cardioprotection via IPC. Ischaemic preconditioning failed to provide cardioprotection in isolated hearts of aged, diabetic Goto-Kakizaki rats compared with younger diabetic rats, likely due to impaired Akt signalling.