Key result
Triangular deformation worsens valve function, while thinner leaflets adapt better but carry higher deterioration risk.
Why the study?
Does configuration deformation and leaflet thickness affect the hydrodynamic performance of transcatheter aortic valves in an in vitro model?
Does configuration deformation and leaflet thickness affect the hydrodynamic performance of transcatheter aortic valves in an in vitro model?
In vitro testing demonstrates that triangular deformation of TAVs severely impairs valve function, and thicker leaflets are less adaptable to deformation, leading to increased regurgitation.
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Triangular TAV deformation impairs function in vitro; hypothesis-generating for leaflet thickness effects, needing in vivo confirmation before practice change.
Feng et al. (2017) studied Transcatheter aortic valve deformation (n=3). Aortic annulus deformation and leaflet tissue thickness vs. Nominal configuration was evaluated on Transvalvular pressure difference, effective orifice area, and regurgitation flow. Triangular deformation produced the poorest valve function, while thinner leaflets were better at adapting to deformation but had a higher risk of deterioration.
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