Key result
Transcatheter aortic valve stenosis dramatically increased peak leaflet shear stress to 115 Pa compared to 87 Pa in sclerosis and 29 Pa in normal valves in computational fluid dynamics simulations.
Why the study?
Does simulated TAV degeneration (sclerosis and stenosis) increase leaflet shear stress and total force on the valve compared to normal TAV?
Does simulated TAV degeneration (sclerosis and stenosis) increase leaflet shear stress and total force on the valve compared to normal TAV?
Computational fluid dynamics simulations reveal that TAV degeneration significantly increases total force and peak leaflet shear stress, highlighting the need for watchful examination for device failure.
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Elevated shear stress in stenotic TAV may raise thrombosis risk; leaves open durability implications pending clinical studies.
Dwyer et al. (2009) studied Transcatheter aortic valve degeneration. Transcatheter aortic valve sclerosis and stenosis vs. Normal transcatheter aortic valve was evaluated on Hemodynamic changes including total force and peak leaflet shear stress. Transcatheter aortic valve stenosis dramatically increased peak leaflet shear stress to 115 Pa compared to 87 Pa in sclerosis and 29 Pa in normal valves in computational fluid dynamics simulations.
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