Key result
Nonideal geometric configurations of transcatheter aortic valves significantly altered hydrodynamics compared to the nominal shape, notably increasing intravalvular regurgitation.
Why the study?
Do nonideal geometric configurations of transcatheter aortic valves alter hydrodynamics compared to nominal shape in an in vitro model?
Do nonideal geometric configurations of transcatheter aortic valves alter hydrodynamics compared to nominal shape in an in vitro model?
p-value: p=<0.001
Nonideal geometric configurations of transcatheter aortic valves demonstrate increased intravalvular regurgitation and altered hydrodynamics in vitro.
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Should not alter TAV deployment yet; leaves open clinical relevance of in vitro findings.
Young et al. (2011) studied Transcatheter aortic valve hydrodynamics (n=3). Variable geometric configurations (elliptical, triangular, undersized, half-constriction) vs. Nominal-sized shape was evaluated on Transvalvular pressure gradient, effective orifice area, and regurgitant fraction (p=<0.001). Nonideal geometric configurations of transcatheter aortic valves significantly altered hydrodynamics compared to the nominal shape, notably increasing intravalvular regurgitation.
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