Key result
ACE inhibitor therapy in elderly hospitalized heart failure patients was administered at similar rates (83% overall) but at significantly lower doses compared to younger patients (p=0.001).
Why the study?
Does age affect the rate and dosage of ACE inhibitor administration in patients hospitalized with heart failure and ejection fraction <=40%?
Population
613 patients admitted to participating hospitals with a primary diagnosis of heart failure with ejection…
Design
Cohort
Authors
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May warrant age-adjusted dosing caution in hospitalized HFrEF; leaves open need for trials on optimal elderly regimens.
Cohort (n=613)
Yes
Does age affect the rate and dosage of ACE inhibitor administration in patients hospitalized with heart failure and ejection fraction <=40%?
p-value: p=0.001
Elderly patients hospitalized with HFrEF receive ACE inhibitors at similar rates to younger patients but at significantly lower doses, driven by factors like lower creatinine clearance and blood pressure.
Rangaswamy et al. (2004) conducted a cohort in Heart failure with ejection fraction <=40% (n=613). ACE inhibitors vs. Younger age groups was evaluated on Adherence to guideline-based medical care (ACE inhibitor administration rate and dosage) (p=0.001). ACE inhibitor therapy in elderly hospitalized heart failure patients was administered at similar rates (83% overall) but at significantly lower doses compared to younger patients (p=0.001).
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