Key result
Female sex in HFrEF is linked to higher LVEF but no significant difference in hospital mortality.
Why the study?
Important differences in comorbidities and clinical characteristics exist between women and men with heart failure, prompting an exploration of the influence of gender on manifestations, complications, and mortality in systolic heart failure.
Does gender influence the clinical manifestations, complications, and mortality of patients hospitalized with systolic heart failure?
Population
1340 patients hospitalized with heart failure
Comparison
Women vs men
Design
Cross-sectional study
Authors
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Does not support sex-specific HF management changes; leaves open whether mortality differences reflect biology or unmeasured confounders.
Cross-Sectional (n=1,340)
No
Does gender influence the clinical manifestations, complications, and mortality of patients hospitalized with systolic heart failure?
Absolute Event Rate: 9.73% vs 2.22%
p-value: p=0.07
In patients hospitalized with systolic heart failure, women experience significantly higher hospital mortality and have higher ejection fractions, whereas men present with more ischemic heart disease and hypertension.
Pourrafsanjani et al. (2025) conducted a cross-sectional in Systolic heart failure (n=1,340). Female gender vs. Male gender was evaluated on Hospital mortality rate (p=0.07). Female patients with systolic heart failure had a higher hospital mortality rate (9.73% vs 2.22%, p=0.07) and mean ejection fraction (35% vs 27.66%, p=0.02) compared to male patients.
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