Key result
Female sex is associated with ~23% lower mortality in HFrEF, alongside nonischemic etiology.
Why the study?
Limited data exist on gender-related differences in etiology and outcomes among patients with heart failure with systolic dysfunction.
Do gender and etiology affect survival and hospitalization outcomes in patients with heart failure with systolic dysfunction?
Observational (n=11,642)
Yes
Do gender and etiology affect survival and hospitalization outcomes in patients with heart failure with systolic dysfunction?
Hazard Ratio: 0.77 (95% CI 0.69–0.85)
Female gender and nonischemic etiology are independently associated with better survival in patients with heart failure with systolic dysfunction.
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Supports sex-specific HF prognosis and management; extends pooled RCT data to guide future trial stratification.
Frazier et al. (2007) conducted an observational in Heart failure with systolic dysfunction (n=11,642). Female gender vs. Male gender was evaluated on All-cause mortality (survival time) (HR 0.77, 95% CI 0.69 to 0.85). Female gender (HR 0.77; 95% CI 0.69-0.85) and nonischemic etiology (HR 0.80; 95% CI 0.72-0.89) were associated with longer survival time in patients with heart failure with systolic dysfunction.
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