In STEMI patients with incomplete reperfusion after primary PCI, women had higher unadjusted 12-month mortality than men (18.8% vs 11.2%), which was not significant after age adjustment (OR 1.16).
Observational (n=2,730)
Yes
Are there sex-related differences in clinical characteristics and prognosis among patients with STEMI and incomplete infarct-related artery reperfusion after primary PCI?
Among STEMI patients with incomplete reperfusion after primary PCI, women present with more unfavorable baseline characteristics and experience worse short- and long-term outcomes, particularly heart failure, compared to men.
Effect estimate: OR 1.16 (95% CI 0.96-1.4)
Absolute Event Rate: 18.8% vs 11.2%
p-value: p=<0.0001
INTRODUCTION: Little is known about gender-related differences in ST-segment elevation myocardial infarction (STEMI) and incomplete infarct-related artery (IRA) reperfusion after primary percutaneous coronary intervention (pPCI). AIM: To evaluate gender-related differences in clinical characteristics and prognosis in patients with STEMI and incomplete IRA reperfusion after pPCI. MATERIAL AND METHODS: From 42,752 STEMI patients hospitalized between 2009 and 2011 in Poland we analyzed a group of 984 (36%) females and 1,746 (64%) males with less than Thrombolysis in Myocardial Infarction (TIMI) grade 3 flow following pPCI. RESULTS: = 0.0016). Heart rate > 100 beats/min was more common in women, while men were more often smokers and presented with sudden cardiac arrest. The most common IRA in women was the left anterior descending artery, and the right coronary artery in men. After adjusting for age statistically significant differences in pharmacotherapy concerned only the use of insulin (OR = 1.31, 95% CI: 1.02-1.68). High risk of death, rehospitalization due to heart failure or cardiac causes, were observed in all patients during the 6-month and 12-month follow-up periods. The risk of heart failure was significantly higher in women than in men. The most significant decrease in survival rates was observed in the in-hospital period. CONCLUSIONS: Among patients with STEMI and post-interventional TIMI flow grade < 3 women have unfavorable baseline characteristics and an adverse short- and long-term prognosis when compared to men.
Zachura et al. (Mon,) conducted a observational in ST-segment elevation myocardial infarction with incomplete infarct-related artery reperfusion after primary percutaneous coronary intervention (n=2,730). Female sex vs. Male sex was evaluated on 12-month mortality (OR 1.16, 95% CI 0.96-1.4, p=<0.0001). In STEMI patients with incomplete reperfusion after primary PCI, women had higher unadjusted 12-month mortality than men (18.8% vs 11.2%), which was not significant after age adjustment (OR 1.16).