Better outcome of ablation for sustained outflow-tract ventricular tachycardia when tachycardia is inducible
Key result
Outflow-tract VT ablation shows ~87% lower recurrence when only a single morphology is inducible.
- P=0.004
- n=54
Why the study?
Does inducibility of ventricular tachycardia improve outcomes of catheter ablation in patients with sustained outflow-tract ventricular tachycardia without structural heart disease?
Population
54 patients without overt structural heart disease who underwent catheter ablation for symptomatic sustained…
Comparison
Catheter ablation guided by inducible sustained… vs Catheter ablation targeting premature…
Design
Cohort
Follow-up
21 ± 19 months
Authors
Discussion
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Member takes
Implication
Single inducible VT morphology was associated with lower outflow-tract VT recurrence after ablation; hypothesis-generating and requires prospective validation before guiding practice.
Study Design
Type
Cohort (n=54)
Structured PICO
Does inducibility of ventricular tachycardia improve outcomes of catheter ablation in patients with sustained outflow-tract ventricular tachycardia without structural heart disease?
P
Population
54 patients (31 men; age, 52 ± 13 years) without overt structural heart disease who underwent catheter ablation for symptomatic sustained VT originating from the right- or left-ventricular outflow region, including the great vessels.
I
Intervention
Catheter ablation guided by inducible sustained ventricular tachycardia (single or multiple morphologies).
C
Comparator
Catheter ablation targeting premature ventricular contractions (PVCs) due to non-inducible ventricular tachycardia.
O
Outcome
Ventricular tachycardia recurrence during follow-up.hard clinical
Main Result
Absolute Event Rate: 6% vs 46%
p-value: p=0.004
In patients with sustained outflow-tract VT without structural heart disease, inducibility of a single VT morphology during ablation is associated with significantly lower recurrence rates compared to non-inducible VT or multiple VT morphologies.
Cite This Study
Choi et al. (2015) conducted a cohort in Sustained outflow-tract ventricular tachycardia without overt structural heart disease (n=54). Catheter ablation with inducible single morphology VT vs. Catheter ablation with non-inducible VT or multiple VT morphologies was evaluated on VT recurrence (p=0.004). Catheter ablation for sustained outflow-tract VT resulted in lower VT recurrence when a single VT morphology was inducible (6%) compared to multiple morphologies (40%) or non-inducible VT (46%) (P=0.004).