Key result
Orthogonal bipolar array catheters detect minute directional cardiac repolarization changes missed by unipolar ARI.
Why the study?
Differential repolarization effects produced by waves propagating in various directions had not been studied, and it was unknown whether electrogram-based methods could detect these differences compared to optical mapping.
Population
6 rabbit Langendorff experiments
Comparison
Orthogonal bipolar egms (rEGM) vs unipolar-based ARI methods
Design
Ex vivo experimental animal study
Authors
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Supports orthogonal bipolar mapping for repolarization assessment in animal models; hypothesis-generating for clinical translation.
p-value: p=<0.01
An orthogonal bipolar approach using equi-spaced array catheters can reliably detect minute local repolarization changes related to activation direction that are missed by traditional unipolar ARI methods.
Massé et al. (2023) studied Cardiac repolarization (n=6). Orthogonal bipolar approach (rEGM) vs. Unipolar ARI methods was evaluated on Detection of directional repolarization differences (p=<0.01). An orthogonal bipolar approach using equi-spaced array catheters successfully detected minute cardiac repolarization changes related to wave front propagation direction (p<0.01), unlike unipolar ARI.
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