Key result
Optical techniques successfully recorded simultaneous activation and repolarization times from 124 sites in guinea pig hearts with high spatial resolution.
Population
Guinea pig hearts (preclinical model)
Design
Preclinical
Authors
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Supports detailed dispersion of refractoriness analysis in preclinical models; leaves open human translation.
Optical transmembrane potential recording provides high spatial resolution data suitable for analyzing the dispersion of refractoriness in cardiac tissue.
Salama et al. (2003) studied spatial inhomogeneity in repolarization. optical technique for epicardial recordings was evaluated on spatial distribution of action potential duration and repolarization times. Optical techniques successfully recorded simultaneous activation and repolarization times from 124 sites in guinea pig hearts with high spatial resolution.
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