Key result
Intracardiac QRS-T E-field vector angles successfully detect repolarization gradients validated by optical mapping.
Why the study?
Repolarization gradients drive arrhythmogenicity but are not clinically mapped due to ambiguous unipolar repolarization time annotations, prompting validation of intracardiac QRS and T electric field direction discrepancy against optical mapping.
Intracardiac QRS and T electric field direction mapping can spatially assess repolarization gradients, potentially offering a clinical tool to stratify regions at risk of re-entrant ventricular tachyarrhythmias.
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Hypothesis-generating for repolarization mapping; leaves open clinical translation pending prospective validation.
Subha et al. (2026) studied Repolarization heterogeneities (n=4). Intracardiac QRS and T E-field direction mapping vs. Optical mapping was evaluated on Correlation of QRS-T angle discrepancy with spatial dispersion of repolarization (SDR) from optical APD80 values. Intracardiac QRS and T E-field vector angles successfully detected repolarization gradients (mean angle 37.45 degrees post-ibutilide vs 21.12 at baseline), validated by optical mapping.
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