Key result
Cardiac rehabilitation improves quality of life and reduces E/e' by ~66% vs usual care.
Why the study?
HFpEF represents over half of heart failure cases worldwide with high morbidity and mortality, but no proven medical treatment has shown a mortality benefit. This study aimed to elucidate the benefit of cardiac rehabilitation in HFpEF.
Does cardiac rehabilitation improve diastolic function, quality of life, and functional capacity in patients with HFpEF?
Population
60 patients with HFpEF
Comparison
Cardiac rehabilitation plus usual medical care vs usual medical care alone
Design
Randomized controlled trial (1:1 randomization)
Follow-up
12 weeks
Authors
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Supports cardiac rehabilitation in HFpEF management; extends RCT evidence to diastolic function and quality-of-life gains.
RCT (n=60)
1:1
Does cardiac rehabilitation improve diastolic function, quality of life, and functional capacity in patients with HFpEF?
Absolute Event Rate: 305.6% vs 69.44%
p-value: p=< 0.001
Cardiac rehabilitation in HFpEF patients significantly improves quality of life, functional capacity, and echocardiographic parameters of diastolic function over 12 weeks.
Hassanein et al. (2021) conducted an RCT in Heart failure with preserved ejection fraction (HFpEF) (n=60). Cardiac rehabilitation vs. Usual medical care was evaluated on Percentage of improvement in Minnesota living with heart failure questionnaire (MLWHFQ) total score (p=< 0.001). Cardiac rehabilitation significantly improved quality of life (MLWHFQ reduction 305.60 vs 69.44, p<0.001) and diastolic function (E/e' reduction 65.96% vs 18.23%, p<0.001) compared to usual care.
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