Key result
Targeting PDE3 isoforms may improve HF clinical responses via cAMP-mediated signaling in cardiac myocytes.
Population
Cardiac myocytes
Design
Review
Authors
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PDE3 isoform targeting in heart failure remains investigational; leaves open whether selective inhibition improves clinical responses.
This review highlights the molecular biology of PDE3 isoforms in cardiac myocytes and their potential as therapeutic targets to improve clinical outcomes in heart failure.
Movsesian et al. (2018) conducted a review in Heart failure. PDE3 inhibitors was evaluated. PDE3 isoforms play important roles in cAMP-mediated signaling in cardiac myocytes, and targeting these enzymes may improve the profile of clinical responses in patients with heart failure.
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