Key result
Virtual dominant frequency ablation terminates or converts in-silico AF in up to ~76% of models.
Why the study?
Does virtual ablation of high dominant frequency areas terminate atrial fibrillation in in-silico models?
Population
In-silico AF models integrating 3-D CT images of the left atrium from 10 patients with persistent AF
Design
Preclinical
Authors
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Cautions against DF-guided ablation in practice; hypothesis-generating from in-silico models and leaves open clinical efficacy.
Does virtual ablation of high dominant frequency areas terminate atrial fibrillation in in-silico models?
p-value: p=<0.001
In-silico modeling suggests that high dominant frequency areas in persistent AF are temporally variable, but their virtual ablation is moderately effective in terminating AF or converting it to atrial tachycardia.
Li et al. (2016) studied Persistent Atrial Fibrillation (n=10). Virtual ablation of high dominant frequency (DF) areas vs. Different extents of ablation was evaluated on Atrial fibrillation termination or conversion to atrial tachycardia (p=<0.001). Virtual ablation of 10%, 15%, and 20% of the highest dominant frequency areas in an in-silico model of atrial fibrillation terminated or changed AF to atrial tachycardia at rates of 40%, 57%, and 76%, respectively.
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