Key result
Cardiac dysfunction markers including EF and ESVi are linked to brain atrophy and cognitive impairment.
Why the study?
Are markers of cardiac dysfunction associated with brain atrophy and cognitive impairment in patients with HFrEF?
Observational
Are markers of cardiac dysfunction associated with brain atrophy and cognitive impairment in patients with HFrEF?
In patients with HFrEF, cardiac dysfunction markers such as ejection fraction and end systolic volume index are associated with structural brain changes and cognitive impairment.
Supports cardiac-brain link in HFrEF; hypothesis-generating, leaves open causality and practice implications.
Lower gray matter volume, and cortical thinning in heart failure are regionally dependent, and independent of age. Patients living with heart failure had higher cortical curvature, but older adults did not. Lower gray matter volume, cortical thinning, and cognitive impairment were associated with markers of cardiac dysfunction, with ejection fraction, and end systolic volume index being better predictors among the older and heart failure cohort than cardiac index.
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Morse et al. (2025) conducted an observational in Heart failure with reduced ejection fraction. Heart failure vs. Older adults without heart failure was evaluated on Brain atrophy (gray matter volume, cortical thinning, cortical curvature) and cognitive impairment. Markers of cardiac dysfunction, specifically ejection fraction and end-systolic volume index, were associated with lower gray matter volume, cortical thinning, and cognitive impairment.
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