Key result
Fasting RV/LV 18F-FDG uptake ratio above ~144% predicts increased mortality in IPAH.
Why the study?
Does the 18F-FDG uptake ratio between the right and left ventricles predict mortality in patients with idiopathic pulmonary arterial hypertension?
Cohort (n=45)
Does the 18F-FDG uptake ratio between the right and left ventricles predict mortality in patients with idiopathic pulmonary arterial hypertension?
p-value: p=0.030 and 0.014
The 18F-FDG uptake ratio between the right and left ventricles on PET imaging is an independent predictor of long-term mortality in patients with idiopathic pulmonary arterial hypertension.
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RV/LV FDG uptake ratio may aid IPAH risk stratification; hypothesis-generating and requires prospective validation before clinical use.
Li et al. (2015) conducted a cohort in Idiopathic pulmonary arterial hypertension (n=45). 18F-FDG PET imaging (cRV/LV uptake ratio) was evaluated on Mortality (p=0.030 and 0.014). The 18F-FDG uptake ratio between the right and left ventricles predicted mortality in IPAH, with worse prognosis for fasting ratio >143.65% (P=0.030) or glucose-loading ratio >120.55% (P=0.014).
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