Key result
Comorbidities drive HFpEF pathophysiology via endothelial inflammation and oxidative stress.
This review highlights the importance of non-cardiac comorbidities in driving endothelial inflammation and oxidative stress as underlying pathophysiological mechanisms in HFpEF.
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Comorbidity management merits attention in HFpEF; extends mechanistic framework but leaves open targeted intervention trials.
Franssen et al. (2015) conducted a review in Heart failure with preserved ejection fraction (HFpEF). Comorbidities play a key role in the pathophysiology of heart failure with preserved ejection fraction by driving endothelial inflammation and oxidative stress.
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