Key result
Modeling vessel compliance in silico alters distal cerebral flow and wall shear stress versus rigid models.
Why the study?
The study was conducted to understand how arterial wall distensibility affects pressure, flow, and the spatial distribution of flow-related properties across different Circle of Willis configurations.
Does a fluid-structure interaction model accounting for arterial compliance alter calculated cerebral blood flow properties compared to a conventional rigid wall model?
Does a fluid-structure interaction model accounting for arterial compliance alter calculated cerebral blood flow properties compared to a conventional rigid wall model?
Incorporating arterial compliance in computational models of cerebral blood flow reveals significant discrepancies in pressure and shear stress compared to rigid wall models.
Rigid-wall cerebral models may misestimate distal WSS; leaves open compliant FSI validation for clinical use.
We conducted an in silico study of blood flow in the brain using two different computational models: fluid–structure interaction (FSI) and conventional rigid wall (CFD). These models were applied to a patient‐specific vascular network derived from MRI data. We used a mid‐fidelity numerical approach called Transversally Enriched Pipe Element Method (TEPEM) to solve the governing equations. In the FSI model, we coupled the TEPEM strategy with an independent‐ring model to account for arterial wall compliance. We compared the FSI and CFD models to understand how arterial wall distensibility affects pressure, flow, and the spatial distribution of flow‐related properties. Additionally, we introduced three synthetic anatomical variations in the Circle of Willis to extend the comparison of the FSI and CFD models to these scenarios. Our results suggest that vessel compliance introduces discrepancies up to mmHg in distal cerebral regions and up to in the Wall Shear Stress. Regarding the anatomical variations on the Circle of Willis, the incomplete configuration introduces discrepancies in derived‐flow quantities as the Time‐Averaged Wall Shear Stress and the Relative Retention Time up to .
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Alvarez et al. (2025) studied Cerebral blood flow. Fluid-structure interaction (FSI) model vs. Conventional rigid wall (CFD) model was evaluated on Pressure, flow, and spatial distribution of flow-related properties. An in silico fluid-structure interaction model accounting for vessel compliance introduced discrepancies in distal cerebral regions and Wall Shear Stress compared to a conventional rigid wall model.
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