March 4, 2022Frontiers in Bioengineering and BiotechnologyOpen Access

Patient-Specific Cerebral Blood Flow Simulation Based on Commonly Available Clinical Datasets

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Why the study?

Cerebral hemodynamics play an important role in cerebrovascular disease development, prompting the development of a numerical framework for modeling patient-specific cerebral blood flow using commonly available clinical datasets.

Does a patient-specific numerical model calibrated with CTA and TCD data accurately reproduce cerebral blood flow in patients with aneurysmal subarachnoid hemorrhage?

Population

59 patients with aneurysmal subarachnoid hemorrhage

Design

Numerical simulation and modeling study

Authors

YSYuanyuan ShenUniversity Medical Center Groningen YWYanji WeiZhejiang Business Technology Institute RBReinoud P.H. BokkersUniversity Medical Center Groningen

Discussion

Member takes

Implication

Framework enables CTA-based cerebral flow simulation in aSAH; hypothesis-generating for personalized vasospasm assessment pending prospective validation.

Structured PICO

Does a patient-specific numerical model calibrated with CTA and TCD data accurately reproduce cerebral blood flow in patients with aneurysmal subarachnoid hemorrhage?

Population

59 adult patients diagnosed with aneurysmal subarachnoid hemorrhage (aSAH) within 4 days after onset (yielding 66 sets of data)

Intervention

Patient-specific cerebral blood flow simulation using Simscape Fluids library in Simulink, calibrated with transcranial Doppler (TCD) and computerized tomography angiography (CTA) data

Comparator

Uncalibrated simulation and conventional 1D model

Outcome

Agreement between numerical simulation results and TCD measurements (assessed by intraclass correlation coefficient [ICC] and Taylor diagram)surrogate

A patient-specific numerical model using commonly available clinical datasets (CTA and TCD) can accurately reproduce cerebral hemodynamics in patients with aneurysmal subarachnoid hemorrhage.

Limitations

Current arterial network did not take into account minor branches on the CoW
Model calibration relies on flow measurement which may be missing in retrospective studies
Uncalibrated model cannot derive reliable absolute blood flow rate

Cite This Study

Shen et al. (2022) studied this question.

synapsesocial.com/papers/6a7226c1e5469ee92be249ce https://doi.org/10.3389/fbioe.2022.835347

View Full Paper

Ask AI

Bookmark

Implication

Framework enables CTA-based cerebral flow simulation in aSAH; hypothesis-generating for personalized vasospasm assessment pending prospective validation.

Patient-Specific Cerebral Blood Flow Simulation Based on Commonly Available Clinical Datasets

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Patient-Specific Cerebral Blood Flow Simulation Based on Commonly Available Clinical Datasets

Discussion

Member takes

Implication

Structured PICO

Limitations

Cite This Study

Also Consider

Also Consider