Key result
Bolus injection of 50 micrograms synthetic human atrial natriuretic factor increased plasma cyclic GMP levels 2.6-fold to 16.6 nM within 6 minutes.
Why the study?
Does a bolus injection of synthetic human atrial natriuretic factor (ANF) increase cyclic GMP and cyclic AMP levels in normal men?
Population
8 normal men
Design
Other
Follow-up
30 minutes
Authors
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Supports cGMP as a biomarker for ANF effects in humans; leaves open clinical or therapeutic applications.
Does a bolus injection of synthetic human atrial natriuretic factor (ANF) increase cyclic GMP and cyclic AMP levels in normal men?
Cyclic GMP rapidly increases following ANF administration, suggesting it serves as a biological marker for circulating ANF in humans.
Gerzer et al. (1985) studied Healthy volunteers (n=8). synthetic human atrial natriuretic factor (ANF) vs. Basal levels was evaluated on cyclic GMP and cyclic AMP levels in plasma and urine. Bolus injection of 50 micrograms synthetic human atrial natriuretic factor increased plasma cyclic GMP levels 2.6-fold to 16.6 nM within 6 minutes.
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