July 28, 2008European Heart Journal
Prognostic threshold levels of NT-proBNP testing in primary care
Why the study?
Does NT-proBNP testing predict mortality and cardiovascular hospitalization in primary care patients with suspected heart failure?
Population
5,875 primary care patients with suspected heart failure in the Copenhagen area, median age 73 years.
Comparison
NT-proBNP testing vs Lower NT-proBNP levels
Design
Cohort
Follow-up
median 1127 days for mortality and 1038 days for CV…
Authors
Discussion
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Member takes
Implication
May support NT-proBNP thresholds for risk stratification in suspected HF; hypothesis-generating and requires prospective validation before guiding triage.
Structured PICO
Does NT-proBNP testing predict mortality and cardiovascular hospitalization in primary care patients with suspected heart failure?
P
Population
5,875 primary care patients with suspected heart failure in the Copenhagen area, median age 73 years.
I
Intervention
NT-proBNP testing (assessment of prognostic threshold levels)
C
Comparator
Lower NT-proBNP levels (reference deciles in Cox proportional hazards regression)
O
Outcome
Mortality and cardiovascular (CV) hospitalizationhard clinical
Specific NT-proBNP threshold levels can effectively risk-stratify primary care patients with suspected heart failure for mortality and cardiovascular hospitalization, potentially optimizing triage for echocardiography.
Cite This Study
Rosenberg et al. (2008) studied this question.