Key result
Cryoinfarction in mice resulted in decreased LV fractional shortening comparable to coronary ligation at 4 weeks, but with delayed progressive adverse remodeling occurring between 4 and 8 weeks.
Why the study?
Does cryoinfarction provide a more reproducible model of myocardial infarction compared to coronary artery ligation in mice?
Population
Murine model (mice)
Comparison
Cryoinfarction induced using a 2- or 3-mm… vs Coronary artery ligation
Design
Preclinical
Follow-up
4 and 8 weeks
Authors
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A novel murine cryoinfarction model provides highly reproducible anterior myocardial infarcts with progressive adverse remodeling, serving as a clinically representative alternative to coronary ligation.
Does cryoinfarction provide a more reproducible model of myocardial infarction compared to coronary artery ligation in mice?
A novel murine cryoinfarction model provides highly reproducible anterior myocardial infarcts with progressive adverse remodeling, serving as a clinically representative alternative to coronary ligation.
Bos et al. (2005) studied Myocardial infarction (mouse model). Cryoinfarction vs. Coronary artery ligation was evaluated on LV fractional shortening, hemodynamics, and remodeling. Cryoinfarction in mice resulted in decreased LV fractional shortening comparable to coronary ligation at 4 weeks, but with delayed progressive adverse remodeling occurring between 4 and 8 weeks.
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