Why the study?
Do ACE inhibitors reduce mortality, morbidity, and functional decline compared to digoxin in very old nursing home patients with heart failure?
Population
19,492 patients aged 85 years and older with congestive heart failure admitted to nursing homes in 5 US states
Comparison
Angiotensin-converting enzyme (ACE) inhibitors vs Digoxin
Design
Cohort
Follow-up
1 year
Authors
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May support ACE inhibitor preference over digoxin in frail elderly HF; leaves open confirmation in randomized trials.
Do ACE inhibitors reduce mortality, morbidity, and functional decline compared to digoxin in very old nursing home patients with heart failure?
ACE inhibitor therapy is associated with improved survival and reduced functional decline compared to digoxin in very old, frail nursing home patients with heart failure.
Giovanni Gambassi (2000) studied this question.
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