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November 1, 1998Journal of Cardiovascular Electrophysiology

The LETR‐Principle: A Novel Method to Assess Electrode‐Tissue Contact in Radiofrequency Ablation

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Why the study?

Does the LETR-Principle accurately assess electrode-tissue contact and predict lesion size in an in vitro porcine ventricular tissue model?

Population

Isolated porcine ventricular tissue (in vitro model)

Design

Preclinical

Authors

OEOLAF J. EICKBakken MuseumFWFRED H. WITTKAMPETBTHOM BRONNEBERGMedtronic (Netherlands)

Discussion

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Implication

Supports LETR-Principle development in ablation models; leaves open human validation before clinical use.

Structured PICO

Does the LETR-Principle accurately assess electrode-tissue contact and predict lesion size in an in vitro porcine ventricular tissue model?

P
Population
Isolated porcine ventricular tissue (in vitro model)
I
Intervention
Low Energy Temperature Response (LETR-Principle) using a custom-made radiofrequency generator (0.1-W power delivery for 10 seconds)
O
Outcome
Correlation between tip temperature response (deltaT) and electrode-tissue contact force, and lesion sizesurrogate

The LETR-Principle safely and accurately indicates electrode-tissue contact and lesion depth in vitro, suggesting potential utility for catheter positioning during radiofrequency ablation.

Cite This Study

EICK et al. (1998) studied this question.

synapsesocial.com/papers/6a0ff29a5725bbd5cc604aa0https://doi.org/10.1111/j.1540-8167.1998.tb00090.x

Topics

AF ablation outcomes
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1<b>Temperature Measurement as a determinant of Tissue Heating During Radiofrequency Catheter ablation</b>: An Examination of Electrode Thermistor Positioning for Measurement Accuracy1995 · 32 citations
  2. 2Temperature Response Following Nontraumatic Low Power Radiofrequency Application1999 · 15 citations
  3. 3Determinants of Lesion Size During Radiofrequency Catheter Ablation: The Role of Electrode‐Tissue Contact Pressure and Duration of Energy Delivery1991 · 266 citations
  4. 4Observations on electrode-tissue interface temperature and effect on electrical impedance during radiofrequency ablation of ventricular myocardium.1990 · 319 citations
  5. 5Tissue Heating During Radiofrequency Catheter Ablation: A Thermodynamic Model and Observations in Isolated Perfused and Superfused Canine Right Ventricular Free Wall1989 · 438 citations