What question did this study set out to answer?

To evaluate the effect of ablation electrode length and orientation on tissue temperature and lesion size during radiofrequency delivery with active saline cooling.

August 4, 1998Circulation

Inverse Relationship Between Electrode Size and Lesion Size During Radiofrequency Ablation With Active Electrode Cooling

Q: What is the clinical evidence from this study?

Study design: Other. Population: Radiofrequency ablation (n=11). Intervention: 2-mm irrigated tip electrode vs. 5-mm irrigated tip electrode. Primary outcome: Lesion depth in perpendicular orientation (mm).

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Key result

Radiofrequency ablation using a 2-mm irrigated tip electrode produced deeper lesions (8.0 vs 5.4 mm) and higher tissue temperatures than a 5-mm electrode in perpendicular orientation.

Why the study?

Does a 2-mm irrigated tip electrode increase lesion size and tissue temperature compared to a 5-mm electrode during radiofrequency ablation?

Population

11 anesthetized dogs (thigh muscle preparation bathed with heparinized canine blood, 148 ablation sites)

Comparison

Radiofrequency ablation using a 7F catheter with… vs Radiofrequency ablation using a 7F catheter with…

Design

Preclinical

Authors

HNHiroshi NakagawaElectrophysiology FWFred H.M. WittkampfElectrophysiology WYWilliam S. YamanashiUniversity of Oklahoma Health Sciences Center

Discussion

Member takes

Implication

May guide irrigated catheter design; leaves open translation to human RF ablation outcomes.

Key Points

To evaluate the effect of ablation electrode length and orientation on tissue temperature and lesion size during radiofrequency delivery with active saline cooling.
Tested 7F catheters with 2-mm and 5-mm irrigated tip electrodes placed perpendicular or parallel to thigh muscle bathed in heparinized blood across 148 sites in 11 anesthetized dogs.
Delivered radiofrequency current at a constant 50 V for 30 seconds during active saline irrigation at 20 mL/min while measuring tissue temperatures at 3.5-mm and 7-mm depths.
In perpendicular orientation, the 2-mm tip drew lower power (26 vs. 36 W) but achieved higher tissue temperatures, greater lesion depth (8.0 vs. 5.4 mm), and larger diameter (12.4 vs. 8.4 mm) than the 5-mm tip.
In parallel orientation, the 2-mm tip drew less power (25 vs. 33 W) and formed deeper lesions (7.3 vs. 6.9 mm) with equivalent diameters (11.1 vs. 11.3 mm) compared to the 5-mm tip.

Structured PICO

Does a 2-mm irrigated tip electrode increase lesion size and tissue temperature compared to a 5-mm electrode during radiofrequency ablation?

Population

11 anesthetized dogs (thigh muscle preparation bathed with heparinized canine blood, 148 ablation sites)

Intervention

Radiofrequency ablation using a 7F catheter with a 2-mm irrigated tip electrode (saline irrigation 20 mL/min, 50 V for 30 seconds)

Comparator

Radiofrequency ablation using a 7F catheter with a 5-mm irrigated tip electrode (saline irrigation 20 mL/min, 50 V for 30 seconds)

Outcome

Tissue temperature at depths of 3.5 and 7 mm and lesion size (depth and diameter)surrogate

Main Result

Absolute Event Rate: 8% vs 5.4%

During radiofrequency ablation with active cooling, a smaller 2-mm electrode creates larger, deeper lesions with less dependence on orientation compared to a 5-mm electrode.

Cite This Study

Nakagawa et al. (1998) studied Radiofrequency ablation (n=11). 2-mm irrigated tip electrode vs. 5-mm irrigated tip electrode was evaluated on Lesion depth in perpendicular orientation (mm). Radiofrequency ablation using a 2-mm irrigated tip electrode produced deeper lesions (8.0 vs 5.4 mm) and higher tissue temperatures than a 5-mm electrode in perpendicular orientation.

synapsesocial.com/papers/6a0ff29a5725bbd5cc604aa1 https://doi.org/10.1161/01.cir.98.5.458

Topics

AF ablation outcomes

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Inverse Relationship Between Electrode Size and Lesion Size During Radiofrequency Ablation With Active Electrode Cooling

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Topics

Inverse Relationship Between Electrode Size and Lesion Size During Radiofrequency Ablation With Active Electrode Cooling

Discussion

Member takes

Implication

Key Points

Structured PICO

Main Result

Cite This Study

Also Consider

Topics

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