Key result
Treatment of obstructive sleep apnea in patients with coronary artery disease significantly reduced the risk of cardiovascular events compared to no treatment (24% vs 58%; HR 0.24; 95% CI 0.09-0.62).
Why the study?
Does treatment of obstructive sleep apnoea reduce cardiovascular events in patients with coronary artery disease?
Population
54 patients with both coronary artery disease and obstructive sleep apnoea, mean age 57.3 +/- 10.1 years
Comparison
Treatment of obstructive sleep apnoea with… vs No treatment for obstructive sleep apnoea
Design
Cohort
Follow-up
median 86.5 +/- 39 months
Authors
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OSA treatment was associated with fewer CV events in CAD; leaves open causality and need for randomized confirmation.
Cohort (n=54)
Does treatment of obstructive sleep apnoea reduce cardiovascular events in patients with coronary artery disease?
Effect estimate: HR 0.24 (95% CI 0.09-0.62)
Absolute Event Rate: 24% vs 58%
p-value: p=<0.01
Treatment of obstructive sleep apnoea in patients with coronary artery disease is associated with a significant reduction in long-term cardiovascular events.
Olivier Milleron (2004) conducted a cohort in Coronary artery disease and obstructive sleep apnoea (n=54). Obstructive sleep apnoea treatment (continuous positive airway pressure or upper airway surgery) vs. No OSA treatment (declined treatment) was evaluated on Composite of cardiovascular death, acute coronary syndrome, hospitalisation for heart failure, or need for coronary revascularisation (HR 0.24, 95% CI 0.09-0.62, p=<0.01). Treatment of obstructive sleep apnea in patients with coronary artery disease significantly reduced the risk of cardiovascular events compared to no treatment (24% vs 58%; HR 0.24; 95% CI 0.09-0.62).
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